Comparative Studies of the Effect of Acid Hydrolysis on the Physicochemical Properties of Ipomoea batatas and Manihot esculenta Starches

Main Article Content

 Emmanuel O. Olorunsola
Boma B. Mohammed

Abstract

Background: Starch is one of the most widely used excipients in the manufacture of tablets and scientists have tried to develop starch from various botanical sources. Ipomoea batatas; sweet potato and Manihot esculenta; cassava are two tropical plants and are good starch sources.


Objectives: The effect of modification by acid hydrolysis on the physicochemical properties of Ipomoea batatas (IB) and Manhot esculentai (ME) starches were studied and compared.


Methods: Starches were extracted from IB and ME; and microcrystalline starches (MCS) were produced by hydrolyzing the native starch (NS) at 54 oC using 6 N HCl for 6 h. The pH, total ash value, hydration capacity, swelling capacity, moisture sorption capacity, percentage moisture loss, particle size analysis, angle of repose, flow rate, Carr's index, Hausner's ratio and powder porosity of the native and microcrystalline starches were determined.


Results: The physicochemical properties of the microcrystalline starch were significantly different from those of the native starch for both IB and ME. While better yield of MCS was obtained from the IB native starch, the physicochemical properties of the ME starch were better improved.


Conclusion: The study has shown that acid hydrolysis improves the physicochemical properties of starch and that IB native starch and ME native starch can be used to produce high quality microcrystalline starch.


Key words: Acid hydrolysis, Ipomoea batatas, Manihot esculenta, microcrystalline starch, physicochemical properties.

Downloads

Download data is not yet available.

Article Details

How to Cite
Olorunsola, EmmanuelO., & Mohammed, B. B. (2012). Comparative Studies of the Effect of Acid Hydrolysis on the Physicochemical Properties of Ipomoea batatas and Manihot esculenta Starches. West African Journal of Pharmacy, 23(2), 29-33. https://doi.org/10.60787/wapcp-23-2-8
Section
Articles
Author Biographies

 Emmanuel O. Olorunsola, Department of Pharmaceutics

 Faculty of Pharmaceutical Sciences,
 Ahmadu Bello University, Zaria - Nigeria. 

Boma B. Mohammed, Pharmaceutical Microbiology

Faculty of Pharmaceutical Sciences,

Ahmadu Bello University, Zaria - Nigeria 

References

Mohammed BB, Isah AB, Ibrahim MA (2009). Influence of compaction pressures on modified cassava starch as a binder in paracetamol tablet formulations. Nig J Pharm Sci 8 (1): 80-88.

Oyi AR, Allagh TS, Olayemi OR (2009). Comparative binding effects of wheat, rice and maize starches in chloroquine phosphate tablet formulation. Research J of Applied Sc., Engineering and Technology 1(2):77-80.

Puchongkararin H, Bergthaller W, Shobsngub S, Varavinil S (2003). Characterization and utilization of acid-modified rice starches for use in pharmaceutical tablet compression. Interscience Journal 55 (4): 464- 475.

Esezobo S (1988). Evaluation of sweet potato starch as a binder and disintegrant for paracetamol tablets. Nig J Pharm Sci 2 (2): 44 -51.

Odeku OA, Itiola OA (2007). Compaction properties of three types of starches. Iranian J Pharm Research 6 (1): 17-23.

Ibezim EC, Ofoefule SI, Omeje EO, Onyishi VI, Odoh UE (2008).The role of ginger starch as a binder in acetaminophen tablets. Scientific Res and Essay 3(2):46- 50.

Bender AE (1990). Dictionary of Nutrition and Technology. Butterworths Boston.

Burrel MM (2003). Starch: The need for improved quality or quantity. J Experimental botany 54 (382): 451- 456.

Bos CE, Bolhuis GK, Lerk CF, Duineveld CAA (1992). Evaluation of modified rice starch: a new excipient for direct compaction. Drug Dev Ind Pharm 18: 93-106.

Yiu PH, Loh SC, Rajan A, Wong SC, Bong CFJ (2008). Physicochemical properties of sago starch modified by acid treatment in alcohol. American J Appl Science 5 (4) : 307-311.

Ohwoavworhua FO, Adeola JI, Kunle OO (2005). Extraction and characterization of Voandezia subterranean (L.) starch: a potential pharmaceutical excipient. J Phytomed and Therap 10 : 6-12.

World Intellectual Property Organisation (1997). Use of microcrystalline starches as tableting excipients. PCI /NL97/00097: 1-5.

Iwuagwu MA, Onyekweli AO (2002). Preliminary investigation into the use of Pleurotus tuber regium powder as a tablet disintegrant. Trop J Pharm Res 1(1): 29-37.

Isah AB, Abdulsamad A, Gwarzo MS, Abbah HM (2009). Evaluation of the disintegrant properties of microcrystalline starch obtained from cassava in metronidazole tablet formulations. Nig J Pharm Sci 8 (2) : 26 -35.

Michoel A, Rombaut P, Verhoye A (2002). Comparative evaluation of co-processed lactose and microcrystalline cellulose with their physical mixtures in the formulation of folic acid tablets. Pharm Dev Technol 7 : 79-87.

Wells SJ, Aulton ME (2007). Pharmaceutical preformulation. In: Aulton ME, ed. The Design and Manufacture of Medicine, 3rd edn. Churchill : Livingstone Elsevier, pp. 336-360.

Staniforth JN, Aulton ME (2007). Powder flow. In: Aulton ME, ed. The Design and Manufacture of Medicine, 3rd edn. Churchill : Livingstone Elsevier, pp. 168-179.