Comparative study of the quality of atorvastatin tablet brands obtained from Lagos, Nigeria

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Oyawaluja B. Olaofe
Adepoju-Bello A. Ayinke
Oyawaluja B. Olaofe
Abibu M. Amedat

Abstract

Background: The quality of any pharmaceutical product significantly affects its effectiveness and safety. Atorvastatin, a widely used medication for managing cholesterol level, relies on meeting established standard for optimal clinical response.


Objective: This research aimed at evaluation of the quality of the leading atorvastatin tablets brands marketed in Lagos, Nigeria.


Methods: The assessments of the quality of eight atorvastatin brands (ATRO1, ATRO2, ATRO3, ATRO4, ATRO5, ATRO6, ATRO7, and ATRO8) were done using British Pharmacopoeia (BP) and United States Pharmacopeia (USP) methods. Physicochemical parameters (thickness, weight uniformity, diameter, friability, and hardness) were evaluated using British Pharmacopoeia (BP) methods, the active ingredient content was quantified using ultraviolet-visible spectrometry, and the dissolution profiles were analyzed using a USP dissolution apparatus II.


Results: All brands met BP specifications for uniformity of weight and thickness. However, ATRO 2, ATRO 6, ATRO 7, and ATRO 8 had larger diameters than BP standard. ATRO1 exceeded the BP specification for friability. The hardness generally fell within acceptable ranges. Regarding percentage purity, only ATRO 1 and ATRO 7 met BP standards. Dissolution profile analysis revealed variations among the brands. Only ATRO 1 and ATRO 7 met the BP requirement of releasing 80% of atorvastatin within 30 minutes.


Conclusion: There are observed variations in physicochemical parameters, percentage purity, and dissolution profiles among the eight brands of atorvastatin tablets and these could potentially impact the clinical effectiveness and safety of the medication. Strict quality control is essential to maintain consistency and efficacy of pharmaceuticals.

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How to Cite
Olaofe, O. B., Ayinke, A.-B. A., Olaofe, O. B., & Amedat, A. M. (2024). Comparative study of the quality of atorvastatin tablet brands obtained from Lagos, Nigeria. West African Journal of Pharmacy, 35(2), 41-56. https://doi.org/10.60787/wajp.vol35no2.354
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Author Biography

Oyawaluja B. Olaofe, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, Lagos.

E-mail: boyawaluja@unilag.edu.ng, 
Telephone: +2348023534167

How to Cite

Olaofe, O. B., Ayinke, A.-B. A., Olaofe, O. B., & Amedat, A. M. (2024). Comparative study of the quality of atorvastatin tablet brands obtained from Lagos, Nigeria. West African Journal of Pharmacy, 35(2), 41-56. https://doi.org/10.60787/wajp.vol35no2.354

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