Health related quality of life of people living with epilepsy in a Neuro-Psychiatric Hospital in Northern Nigeria
Main Article Content
Abstract
Background: Epilepsy is a chronic devastating disorder that affects patients' quality of life irrespective of whether anti-epileptic drugs (AEDs) are being used.
Objectives: The objective of the study was to assess the health related quality of life of people living with epilepsy and its determinants in a Neuro-Psychiatric Hospital in Nigeria.
Methods: The cross sectional study involved 182 patients living with epilepsy that are on therapy with AEDs, sampled conveniently and interviewed between March-June 2015. Health Related Quality Of Life (HRQOL) was the primary outcome using items from Quality of Life In Epilepsy inventory (QOLIE-31). The data obtained were analyzed using Statistical Package for Social Sciences (SPSS 19.0). A P-value < 0.05 was considered statistically significant.
Results: Out of 182 patients, who participated in the study, 53.9% were male and 46.1% were female. The average age was 27.6±8.5 years. The overall HRQOL mean QOLIE-31 score of 57.46±14 was low relative to the expected normal value of 60.00±0.0 for people living with epilepsy. The three sub-scales considered normal with scores higher than 60.0 include cognitive functioning (65.67±21.85), social functioning (63.13±23.23) and medication effects (72.4±22.3). The most severely affected domain with sub-optimal scores was physical functioning (36.62±33.02) followed by seizures worry (50.19±20.10) and emotional well-being of 54.77±21.67. Being male was significantly associated with poor overall HRQOL (p-value = 0.021).
Conclusion: The HRQOL of the studied population being managed at the hospital is poor relative to group norm for people living with epilepsy. The most severely affected domain was physical functioning followed by seizures worry. It is important to strengthen the socioeconomic and psychological support in addition to optimal medication utilization to enhance HRQOL of the patients receiving AEDs.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
How to Cite
Share
References
Alwan A, MacLean DR, Riley LM, d'Espaignet ET, Mathers CD, Stevens GA (2010). Monitoring and surveillance of chronic non-communicable
diseases: progress and capacity in high-burden countries. Lancet; 376: 18618. Medline:21074258 doi:10.1016/S0140-6736(10)61853-3
Ngugi AK, Bottomley C, Kleinschmidt I, Sander JW, Newton CR (2010). Estimation of the burden of active and life-time epilepsy: a metasanalytic approach. Epilepsia; 51(5):883-90. doi: 10.1111/j.1528-1167.2009.02481.x.Epub2010Jan7. https://www.nice.org.uk/guidance/cg137 Accessed May 20, 2016
World Health Organization (2011). UN Highlevel Meeting on NCDs: Summary report of the discussions at the round tables. Geneva: WHO.
Available at: http://www.who.int/nmh/events/moscow_ncds_2011/round_tables_ summary.pdf. Accessed: 28 March 2018.
Sander J. (2003). The Epidemiology of Epilepsy revisited. Current Opinion in Nuerology 16(2):165-70.
Paul A, Adeloye D, George-Carey R, Kolcić I, Grant L, Chan KY (2012). An estimate of the prevalence of epilepsy in Sub–Saharan Africa: A
systematic analysis. Journal of Global Health; 2 (2): 020405. www.jogh.org doi: 10.7189/jogh.02.020405.
Akpan, M.U. (2013).Teacher's knowledge and attitude towards seizure disorder: a comparative study of urban and rural school
teachers in Akwa Ibom state, Nigeria. Nigeria Journal of Clinical Practice; 16(3): 365-370.
Al-Khamis FA (2016). Spectrum of neurological disorders: Neurology clinic experience of university tertiary care hospital. Saudi Journal
of Health Sciences;5:11-4. Available at: http://www.saudijhealthsci.org/text.asp?2016/5/1/11/182859
Onwuekwe I, Ezeala-Adikaibe B (2011). Prevalence and distribution of neurological disease in a neurology clinic in Enugu, Nigeria.
Annals of Medicine and Health Sciences Research. 1: 63-67.
National Clinical Guideline Centre (NCGC, 2016). Epilepsies: diagnosis and management.NICE guidelines [CG137] Published date: January 2012 Last updated: February 2016. Available at: https://www.nice.org.uk/guidance/cg137 Accessed May 20, 2016
Komolafe MA, Sunmonu TA, Afolabi O T (2012). The social and economic impacts of epilepsy on women in Nigeria. Epilepsy & Behaviour ; 24 (Suppl.1):97-101.
Saadi A, Patenaude B, Mateen FJ.(2016). Quality of life in epilepsy-31 inventory (QOLIE- 31) scores: A global comparison. Epilepsy &
Behaviour; 65: 13-17. doi: 10.1016/j.yebeh.2016.09.032.
Adewuya AO, Oseni SB (2005). Impact of psychiatric morbidity on parent-rated quality of life in Nigerian adolescents with epilepsy.
Epilepsy & Behaviour; 7: 497-501.
Fawale MB, Owolabi MO, Ogunniyi A (2014). Effects of seizure severity and seizure freedom on the health-related quality of life of an African population of people with epilepsy. Epilepsy & Behaviour; 32:9-14.
Onwuekwe IO, Unaogu N, Aguwa EN and Ezeala-Adikaibe B (2015). Health-Related Quality of Life and its Determinants in Adult
Nigerians with Epileptic Seizures. Austin Journal Neurological Disorders Epilepsy; 2(1): 1013.
Nabukenya, A.M., Matovu, J.K.B., WabwireMangen, F., Wanyenze, R.K., Makumbi, F. (2014). Health-related quality of life in epilepsy patients receiving anti-epileptic drugs at National Referral Hospitals in Uganda: a crosssectional study. Health and Quality of Life Outcomes. 12:49.
Adebayo, P.B., Akinyemi, R.O., Oluwole, F., Ogun, S.A., Ogunniyi, A (2014). Impact of somatic comorbidities on quality of life of
patients living with epilepsy in Sagamu. Nigeria Acta Neurology of Scandinavia; 130:387–393.
Osakwe C, Otte WM, Alo C (2014). Epilepsy Prevalence, potential causes and social beliefs in Ebonyi State and Benue State Nigeria. Epilepsy Research 108: 316-326.
Bachok, N., Jiman, Z., Aishah, K. (2013). The quality of life of people with epilepsy at a tertiary referral centre in Malaysia. Health and
Quality of Life Outcomes; 11: 143. https://hqlo.biomedcentral.com/track/pdf/10.1186/1477-7525-11-143
Foppe van Mil JW and Fernandez-Llimos F (2013).What is 'pharmaceutical care' in 2013. Pharmacy Practice (Granada); 11(1): 1–2. PMCID: PMC3780505 PMID: 24155842
Losada-Camacho M, Guerrero-Pabon MF, Garcia-Delgado P, Martínez-Martinez F (2014). Impact of a pharmaceutical care programme
on health-related quality of life among women with epilepsy: a randomised controlled trial (IPHIWWE study). Health and Qual Life Outcomes; 12: 162. doi: 10.1186/s12955-014-0162-8. PMCID: PMC4236797
American Society of Hospital Pharmacists (ASHP) 1993. ASHP statement on pharmaceutical care. American Journal of Hospital Pharmacy. 50:1720-3
The Creative Research Systems. The complete survey software solution since 1982. Research Aids. Available at www.surveysystem.com/sscalc.html (Accessed February 2011).
Vickrey BG, Perrine KR, Hays RD, Hermann BP, Cramer JA, Meador KJ, Devinsky O (1993). Scoring Manual for the QOLIE-31, Version 1.0
Santa Monica, CA: RAND Corporation 1776 Main Street, Santa Monica, California 90401-3208.
Nubukpo P1, Clément JP, Houinato D, Radji A, Grunitzky EK, Avodé G, Preux PM (2004). Psychosocial issues in people with epilepsy in
Togo and Benin (West Africa) II: quality of life measured using the QOLIE-31 scale Epilepsy & Behaviour ; 5(5):728-34
Cramer JA, K. Perrine K, Devinsky O, BryantComstock L, Meador K, Hermann B (1998). Development and cross-cultural translations of a 31 item quality of life in epilepsy inventory Epilepsia, 39, pp. 81–88 [General epilepsy population norms]
Benn EK, Hauser WA, Shih T (2008). Estimating the incidence of first unprovoked seizure and newly diagnosed epilepsy in the low-income urban community of northern Manhattan, New York City. Epilepsia; 49: 1431–1439
Mahrer-Imhofa R, Jaggib S, Bonomoc A, HedigeraH,Eggenschwilerc P, Krämerc G, Oberholzerc E (2013). Quality of life in adult
patients with epilepsy and their family members. Seizure; 22 (2): 128–135 doi:10.1016/j.yebeh.2007.11.013 DOI: 10.1016/j.yebeh.2007.11.013
Rafael F, Houinato D, Nubukpo P, Dubreuil CM, (2010). Sociocultural and psychological features of perceived stigma reported by
people with epilepsy in Benin. Epilepsia; 51(6):1061-8
Baker GA. (2002). The Psychosocial Burden of Epilepsy. Epilepsia 43(s6):26-30. DOI: 10.1046/j.1528-1157.43.s.6.12.x
Jacoby, A., & Baker, G. A. (2008). Quality-of-life trajectories in epilepsy: A review of the literature. Epilepsy & Behavior; 12(4): 557-571
Nabukenya AM, Matovu JKB,Wabwire-Mangen F, Wanyenze RK and Makumbi F (2014). Healthrelated quality of life in epilepsy patients
receiving anti-epileptic drugs at National Referral Hospitals in Uganda: a cross-sectional study. Health and Quality of Life Outcomes 12:49 DOI: 10.1186/1477-7525-12-49
Aydemir N, Snape D (2009). Multiple impacts of epilepsy and contributing factors: findings from an ethnographic study in Vietnam. Epilepsy & Behaviour 16(3):512–520
UCB Pharma SA (2008). Epilepsy and Quality of life: Fact Sheet. GPSRC CNS 081b PR TA 0508 Available at: www.ucb.com/_up/ucb_com.../Epilepsy_and_Quality_of_Life.pdf