Perception, prevalence, and pattern of complementary and alternative medicine use among adults living with sickle cell disease in Lagos, Nigeria.
Main Article Content
Abstract
Background: Nigeria has the largest population of people with Sickle Cell Disease (SCD). About 2.3% of the population suffer from the disease while about 25% are healthy carriers of the sickle cell gene. Painful crises are usually the common cause of frequent hospitalization among people living with SCD, hence, majority of these patients are now turning to the use of Complementary and Alternative Medicines (CAM).
Objectives: This study determined the perception, prevalence and pattern of CAM use among adults living with SCD in Lagos, Nigeria.
Methods: A cross-sectional survey was conducted among 301 SCD. Adults in Lagos State, from April to November 2019. Respondents were interviewed using a semi-structured pretested questionnaire. Descriptive, bivariate and multivariate analyses were conducted using SPSS Version 22. Level of significance was set at p<0.05%.
Results: Majority of respondents were between 25-34 years with a mean age of 30 ± 7.8 years. Three-fifth 181(60.1%) of respondents had good knowledge of CAM, while 177 (58.8%) had a positive perception towards CAM use. All respondents 301(100%) confirmed the use of CAM. The commonest CAM used was relaxation 238 (24.4%). Knowledge of CAM showed statistically significant associations with marital status, level of education and income (p<0.05). Respondents who had secondary level of education and above were less likely to use CAM compared to those who had lower education (OR= -1.011; 95% CI = 0.159-0.831)
Conclusion: CAM use is very common among adults with SCD. There is need for evidence-based research to evaluate the efficiency, effectiveness and safety of CAM.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
How to Cite
Share
References
Platt OS, Brambilla DJ, Rose WF, Milner PF, Castro O, Steinberg MH, Klugg PP (1994). Mortality in Sickle Cell Disease. Life Expectancy and Risk Factors for Early Death. New England Journal of Medicine. 330 (23): 1639 - 44. DOI :10.1056/nejm199406093302303.
Modell B, Darlison M (2008). Global Epidemiology of Haemoglobin Disorders and Derived Service Indicators. Bulletin of the World Health
Organization 86(6):480-487.
Afolayan JA, Jolayemi FT (2011). Parental Attitude to Children with Sickle Cell Disease in Selected Health Facilities in Irepodun Local Government. Studies on Ethno-Medicine 5 (1):33-40.
Anie KA, Egunjobi FE, Akinyanju OO (2010). Psychosocial impact of sickle cell disorder: Perspectives from a Nigerian setting. Globalization
and Health 6(2).https://doi.org/10.1186/1744-8603-6-2
Galadanci N, Wudil BJ, Balogun TM, Ogunrinde GO, Akinsuli A, Hasan-Hanga F, Mohammed AS, Kehinde MO, Olaniyi JA, Diaku-Akinwunmi IN, Brown BJ, Adeleke S, Nnodu OE, Emodi I, Ahmed S, Osegbue AO, Akinola N, Opara HI, Adegoke SA, Aneke J, Adekile AD. (2014). Current Sickle Cell Disease Management Practices in Nigeria. International Health 6(1):23-28.doi:10.1093/inthealth/iht022.
Edwards CL, Scales MT, Loughlin C, Bennett GG, Harris-Peterson S, De Castro LM, Whitworth E, Abrams M, Feliu M, Johnson S, Wood M, Harrison O, Killough A (2005). A brief review of the pathophysiology, associated pain, and psychosocial issues in sickle cell disease. International Journal of Behavioral Medicine 1 2 (3): 171-9. doi: 10.1207/s15327558ijbm1203_6. PMID: 16083320.
Ballas, S. K., Kesen, M. R., Goldberg, M. F., Lutty, G. A., Dampier, C., Osunkwo, I., Wang, W. C., Hoppe, C., Hagar, W., Darbari, D. S., Malik, P (2012). Beyond thedefinitions of the phenotypic complications of sickle cell disease: An update on management. The Scientific World Journal [949535]. https://doi.org/10.1100/2012/949535
Myrvik MP, Brandow AM, Drendal AL, Yan K, Hoffmann RG, Panepinto JA (2013). Clinically Meaningful Measurement of Pain in Children with Sickle Cell Disease. Pediatric Blood & Cancer 60 (10):1689-1695.
Barnes PM, Powell-Griner E, McFann K, Nahin RL (2002). Complementary and alternative medicine use among adults: United States, Advance Data 343:1-19.
World Health Organization. WHO traditional medicine strategy 2002-2005. Geneva WHO; 2002.
Fan K (2005). National Centre for Complementary and alternative medicine website. Journal of the Medical Library Association 93(3):410-412.
Pal SK (2002). Complementary and alternative medicine?: An overview. Current Science 82:5-10.
Busari AA, Mufutau MA (2017). High prevalence of complementary and alternative medicine use among patients with sickle cell disease in a tertiary hospital in Lagos , South West , Nigeria. BMC Complementary and Alternative Medicine 17:299;1-8. DOI 10.1186/s12906-017-1812-2
WHO (2000). General guidelines for methodologies on research and evaluation of traditional medicine WHO/EDM/TRM/2000. Geneva World Health Organization 2000.
Berretta M, Della Pepa C, Tralongo P, Fulvi A, Martellotta F, Lleshi A, Nasti G, Fisichella R, Romano C, De Divitiis C, Taibi R, Fiorica F, Di Francia R, Di Mari A, Del Pup L, Crispo A, De Paoli P, Santorelli A, Quagliariello V, Iaffaioli RV, Tirelli U, Facchini G (2017). Use of Complementary and Alternative Medicine (CAM) in cancer patients: An Italian multicenter survey. Oncotarget 11;8(15):24401-24414. doi: 10.18632/oncotarget.14224. PMID: 28212560; PMCID: PMC5421857.
Ibrahim RI,Hassali MA, Saleem F, Haydar F, Tukmagi Al, Dawood TO (2017). Use of Complementary and Alternative Medicines: A Cross-Sectional Study among Hypertensive Patients in Iraq. Journal of Pharmaceutical Health Services Research 2107 ; 9(1). https://doi.org/10.1111/jphs.12209,
Onyiapat JE, Okoronkwo IL, Ogbonnaya NP (2011). Complementary and Alternative Medicine Use Among Adults in Enugu, Nigeria. Bio Med Cen Complementary Complementary and Alternative Medicine 11: (19). DOI: https://doi.org/10.1186/1472-6882-11-19
Ogbera AO, Dada O, Adeyeye F, Jewo PI (2010). Complementary and Alternative Medicine Use in Diabetes Mellitus. West African Journal of Medicine 29:158-62.
Astin JA (1998). Why Patients Use Alternative Medicine: Results of a National Study. The Journal of the American Medical Association 279 (19) : 1548-1553. doi:10.1001/jama.279.19.1548.
Crawford NW, Cincotta DR, Lim A, Powell CV (2006). A Cross-Sectional Survey of Complementary and Alternative Medicine Use by Children and Adolescents attending the University Hospital of Wales . Bio Med C en Complementary Complementary Alternative Medicine 6(16). DOI: https://doi:10.1186/1472-6882-6-16
Astin JA, Marie A, Pelletier KR, Hansen E, Haskell WL (1998). A review of the Incorporation of Complementary and Alternative Medicine by Mainstream Physicians. The Archives of Internal Medicine. 158(21):2303-2310.
Clement YN, Morton-Gittens J, Basdeo L, Blades A, Francis MJ, Gomes N et al (2007). Perceived efficacy of herbal remedies by users accessing primary healthcare in Trinidad. BioMed Cen Complementary and Alternative Medicine 7 (4). https://doi.org/10.1186/1472-6882-7-4
Danesi MA, Adetunji JB (1994). Use of alternative medicine by patients with epilepsy: a survey of 265 epileptic patients in a developing country Epilepsia 35:344-51.
Ama KE, Frank E, Victor E (2011). Controlling sickle cell disease in Ghana - ethics and options. Pan African Medical Journal 10: (14) . doi: 10.4314/pamj.v10i0.72223
Thompson WE, Eriator I (2014). Pain Control in Sickle Cell Disease Patients?: Use of Complementary and Alternative Medicine. Primary Care & Health Services Section. Pain Medicine 15: 241-246.
Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, Van Rompay M, Kessler RC (1998). Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. The Journal of the American Medical Association 280(18):1569-1575.
Steinberg MH (1999). Management of sickle cell disease. The New England Journal of Medicine 23 340(13):1021-30.
Oshikoya KA, Senbanjo IO, Njokanma OF, Soipe A (2008). Use of complementary and alternative medicines for children with chronic health conditions in Lagos. Bio Med Cen Complementary and Alternative Medicine 6:(16):8:66.
Majumdar S, Thompson W, Ahmad N, Gordon C, Addison C (2013). The Use and Effectiveness of Complementary and Alternative Medicine for Pain in Sickle Cell Anemia. Complementary Therapies in Clinical Practice 19 (4): 184 - 7. doi: 10.1016/j.ctcp.2013.05.003.
Ahwinahwi US, Chukwudi K (2016). Perception and use of complementary and alternative medicine among undergraduate students in a Nigerian university. Journal of Applied Pharmaceutical Science 6(6). 96-101.
Izzo AA, Ernst E (2001). Interactions between Herbal Medicines and Prescribed Drugs: A Systematic Review. Drugs 61 (15): 2163-2175. 10.2165/00003495-200161150-00002.
Quandt SA, Verhoef MJ, Arcury TA, Lewith GT, Steinsbekk A, Kristoffersen AE, Wahner-Roedler DL, Fønnebø V (2009). Development of an international questionnaire to measure use of complementary and alternative medicine (I-CAM-Q). Journal of Alternative and Complementary Medicine. 15(4):331-9. doi: 10.1089/acm.2008.0521. PMID: 19388855; PMCID: PMC3189003.
Mohamad AH, Hibeh S, Abdalla El-Lakany, Maha AE, Samer K, Mohamad A, Farah N (2019). Beliefs, practices and knowledge of community pharmacists regarding complementary and alternative medicine: national cross-sectional study in Lebanon. BMJ Open9 (3); e025074 Doi.101136/bmjopen-2018-025074..
Mandi LF, Divya AP, Ananda S, Liu RJ (2008). Physicians and patient attitude towards complementary and alternative medicine in obstetrics and gynecology. BioMed Cen Complementary and Alternative Medicine 8(35). doi 10119+/1472-6882-8-35.
Hyland ME, Lewith GT, Wetoby C 92003). Developing a measure of attitudes: the holistic complementary and alternative medicine
questionnaire. Complementary Therapies in Medicine 2:33-38. Doi: 10.1016F50965-2299(02)001 13-9.
Ameade EP, Amalba A, Helegbe GK, Mohammed BS (2016). Medical students' knowledge and attitude towards complementary and alternative medicineA survey in Ghana. Journal of Traditional and Complementary Medicine 6(3)230-6.
Albadr BO, Alrukban M, Almajed J, Alotaibi K, Alangari A, Bawazir A, Aljasser A (2018). Attitude of Saudi medical students towards complementary and alternative medicine. Journal of family and community medicine 25(2):120-126.
Hughes EF, Jacobs BP, Berman BM (2005). In: Tierney LM, SJ MP, Papadakis MA, editors. Complementary and alternative medicine in current medical diagnosis and treatment. New York: McGraw-Hill 1696-719.
Amira CO, Okubadejo NU (2007). Frequency of complementary and alternative medicine utilization in hypertensive patients attending an
urban tertiary care centre in. BioMed Cen Complementary and Alternative Medicine 7: 30. doi:10.1186/1472-6882-7-30.
World Health Organization (2002). Traditional Medicine. Strategy 2002-2005. Geneva: Switzerland www.who.int/iris/handle/10665/67163/ [Accessed 2019 Feb 11].
World Health Organization (2011). Programmes and Projects. Traditional Medicine.
World Health Organization (2005). National Policy on Traditional Medicine and Regulation of Herbal Medicines- Report of A WHO Global Survey.
Aliyu UM, Awosan KJ, Oche MO, Taiwo AO, Jimoh AO, Okuofo EC (2017). Prevalence and correlates of complementary and alternative medicine use among cancer patients in usmanu danfodiyo university teaching hospital, Sokoto, Nigeria. Nigerian Journal of Clinical Practice 20:1576-83
Barnes PM, Bloom B, Nahin RL (2008). Complementary and alternative medicine use among adults and children: United States, 2007. National Health Statistics Reports (12):1-23.
Sibinga EM, Shindell DL, Casella JF, Duggan AK, Wilson MH (2006). Pediatric Patients with Sickle Cell Disease: Use of Complementary and Alternative Therapies. Journal of Alternative and Complementary Medicine 12(3):291-8.
Yoon SL, Blac S (2006). Comprehensive, integrative management of pain for patients with SCD. Journal of Alternative and Complementary Medicine 12:995-1001.
Gerson Cwilich R, Serrano Olvera A, Villalobos Prieto A (2006). Complementary and alternative medicine (CAM) in Mexican patients with cancer. Clinical and Translational Oncology. 8:200-7.
Oreagba IA, Oshikoya KA, Amache M (2011). Herbal medicine use among urban residents in Lagos Nigeria. BioMed Cen Complementary and Alternative Medicine 1: 11(17).
Benoit BN, Seth KA, George JD, Kwabena DA, Eunice D, Abigail A (2018). In Vitro Antioxidant Potential and Effect of a Glutathione-Enhancer Dietary Supplement on Selected Rat Liver Cytochrome P450 Enzyme Activity. Hindawi Evidence-Based BioMed Cen Complementary and Alternative Medicine 7462839 https//doi.org/101155/2018/7462839. 2018; [Assessed 2019 Jun 18].
Fugh-Berman A (2000). Herb-drug interactions. Lancet 355:134-8.
Hsiao-yun Annie Chang, Marianne Wallis, Evelin Tiralongo (2011). "Use of Complementary and Alternative Medicine among People with Type 2 Diabetes in Taiwan: A Cross-Sectional Survey", Evidence-Based Complementary and Alternative Medicine ID 983792, 8 pages, 2011. https://doi.org/10.1155/2011/983792
Okoronkwo I, Onyia-Pat J, Okpala P, Agbo M, Ndu A (2014). Patterns of Complementary and alternative medicine use, perceived benefits and adverse effects among adult users in Enugu urban, Southeast Nigeria. Hindawi Evidence-Based Complementary and Alternative Med https://doi,org/10.1155/2014/239372.
Pommier J, Billot L, Mouchtouris A, Deschamps JP, Romero MI, Zubarew T (2002). French adolescent attitudes towards informal care for physical and emotional or relational problems. Acta Paediatrica 9(4(1)):466-74.
Patterson C, Arthur HA (2009). Complementary and alternative medicine questionnaire for young adults. Integrative Medicine Insights 4:1-11.
Hijazi MA, Shatila H, El-Lakany A, Ela AM, Kharroubi S, Alameddine M, Naja F (2019). Beliefs, practices and knowledge of community pharmacists regarding complementary and alternative medicine: national cross-sectional study in Lebanon. BMJ Open 9: e025074. doi:10.1136/ bmjopen-2018-025074