Comparative efficacy and efficiency profile of some commercially available antacids in the Nigerian pharmaceutical market.
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Abstract
Background: Antacids are the substances most commonly used by the patients to obtain fast symptomatic relief from dyspepsia. They are weak bases which neutralize the gastric acid and raise the pH of the gastric contents. The potency of antacids depends on their acid neutralizing capacity (ANC). The ANC varies from one product to the other depending on their formulations.
Objectives: This study evaluated rate and extent of acid neutralization of some antacid formulations available in the Nigerian market.
Methods: Ten liquid formulations were sampled from pharmacies, stored according to manufacturer's recommendations before analysis. All samples were coded by an independent researcher (blinding) and studied for their acid neutralizing capacity. Both acid neutralizing capacity and the neutralizing efficiency was studied for all sampled antacids using the British Pharmacopoeia 2013 method. Constituents were also noted for pharmacotherapy review. Analysis was carried out in triplicates and data analysed using analysis of variance.
Results: Six of the ten antacid preparations satisfied all the conditions stipulated for an efficient and efficacious antacid in the BP. The ANC among the liquid formulations was highest for ANCS 1g 27.51±0.05 and lowest for ANCS 1j 20.13± 0.17 antacid formulations. Two products failed the efficiency test while two others failed to neutralize the acid at both 10 and 20 minutes as recommended in the official reference.
Conclusion: Six of the antacids passed the official test for effectiveness and efficiency while the remaining four either failed one or both tests.
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References
Smith DGG, and Arson JK (2002). Oxford text book of clinical pharmacology and drug therapy. 3rd ed. New York: Oxford.
Ching C, and Lam S (1994). Antacids: Indications and Limitations. Drugs.47(2):305-317.
Sathoskar RS, Bhandarkar SD, and Rege NN (2009). Pharmacology and pharmacotherapeutics. 21st ed. Mumbai: Popular prakashan.
Thompson WG (2009). Antacids. A publication of the International Foundation for Functional Gastrointestinal Disorders (IFFGD). IFFGD; cited]; Available from: www.aboutgerd.orglibrary/download/520.
Amandeep K, Robin S, Ramica S, and Sunil K (2012). Peptic Ulcer: A Review on Etiology and Pathogenesis. International Research Journal of
Pharmacy.3(6):34 - 38.
Sostres C, Carrera-Lasfuentes P, Benito R, Roncales P, Arruebo M, Arroyo MT, Bujanda L, Garcia-Rodriguez LA and Lanas A. (2015). Peptic Ulcer Bleeding Risk: The Role of Helicobacter Pylori Infection in NSAID/Low-Dose Aspirin Users. The American Journal of Gastroenterology.110:684-689.
Wang FW, Tu MS, Mar GY, Chuang HY, Yu HC, Cheng LC, and Hsu PI (2011). Prevalence and risk factors of asymptomatic peptic ulcer disease in Taiwan. World Journal of Gastroenterology.17(9):1199-1203.
Frise CJ, and Nelson-Piercy C. (2012). Peptic ulcer Disease in pregnancy. Journal of Obstetrics and Gynaecology.32(8):804.
Overmier JB, and Murison R (2013). Restoring Psychology's Role in Peptic Ulcer. Applied Psychology: Health and Well-Being.5(1):5-27.
Brown M, and Bennett P (2008). Clinical Pharmacology. 10th ed. Edinburgh: Churchil Livingstone.
Jakaria M, Zaman R, Parvez M, Islam M, Haque MA, Sayeed MA, and Ali MH (2015). Comparative Study among the Different Formulation of Antacid Tablets by Using Acid-Base Neutralization Reaction. Global Journal of Pharmacology.9(3):278-281.
Tripathi KD. (2008). Essentials of Medical pharmacology. 6th ed. New Gelhi: Jaypee.
Jagadesh K, and Chidananda K. (2015). Study of Acid Neutralizing Capacity of Various Antacid Formulations. Asian Journal of Pharmaceutical Technology & Innovation.3(12):113 - 120.
Hilal-Dandan R, and Brunton L. (2014). Goodman and Gilman Manual of pharmacology and therapeutics. 2nd ed: McGraw-Hill
Herzog P, and Holtermuller KH. (1982). Antacid therapy: changes in mineral absorption. Scandinavian Journal of Gastroenterology
Suppl.75:56-62.
Pavlovic BM, Jovonovic SS, Stevanovic V, and Trajkovic SR. (2007). Optimisation method used for aluminium based antacid preparation. Chemical Industry and Chemical Engineering Quarterly.13(2):60 - 67.
Neuvonen PJ. (1991). The effect of magnesium hydroxide on the oral absorption of ibuprofen, ketoprofen and diclofenac. British Journal ofClinical Pharmacology.31(3):263 -266.
Bhardwaj L, Sharma PK, and Malvi R. (2011). A Short Review on Gastro Retentive Formulations for Stomach Specific Drug Delivery: Special Emphasis on Floating In situ Gel Systems. African Journal of Basic & Applied Sciences.3(6):300 - 312.
Moayyedi P, Soo S, Deeks J, Forman D, Harris A, Innes M, and Delaney B (2003). Systematic review: antacids, H2-receptor antagonists, prokinetics, bismuth and sucralfate therapy for non-ulcer dyspepsia. Alimentary Pharmacology and Therapeutics.17(10):1215-27.
Houshia OJ, Abu Eid M, Zaid O, Zaid M, and Al-daqqa N. (2012). Evaluation of the Effectiveness of the Acid-Neutralizing Contents of Selected Palestinian Folk Medicinal Herbs. Advances in Pure and Applied Chemistry.1(4):77 - 79.
Vedavathi H, Tejasvi TS, and Revankar SP. (2013). Evaluation of cost effectiveness and efficacy of commonly used different antacid gel preparations. International Journal of Basic Clinical Pharmacology.2:788-791.
Katakam P, Tantosh NM, Aie shy A, Rajab LJ, Elfituri AA. (2010). A Comparative Study of the Acid Neutralizing Capacity of Various Commercially Available Antacid Formulations in Libya. Libiyan journal of medical research.7(1):41 - 49.
British Pharmacopoeia Commission. (2013). British Pharmacopoeia 2013. BPC, editor. London: TSO.
Carey RM, and Padia SH. (2016). Primary Mineralocorticoid Excess Disorders and Hypertension. In: Jameson JL, De Groot LJ, de Kretser DM, Giudice LC, Grossman AB, Melmed S, Potts JT, Weir GC, editors. Endocrinology: Adult and Pediatric (Seventh Edition): Saunders. p.
Stormer FC, Reistad R, and Alexander J. (1993). Glycyrrhizic acid in liquorice- evaluation of Health Harzard. Food Chemical Toxicology.31(4):303 - 312.
MacCara ME, James NJ, and Barry G. (1985). Acid neutralization capacity of Canadian antacid formulations. Canadian Medical Association
Journal.132:523 - 527.